Novel Aspects of Modeling Genetic Architectures of Complex Traits

The challenge of missing heritability is well documented. This session moves beyond standard models of genetic architecture to learn how the complex evolutionary history of a species has shaped different aspects of complex traits.

Learning Objectives:
1. Identify key determinants of gene discovery in Genome Wide Association Studies (GWAS) and Rare Variant Association Studies (RVAS).
2. Examine the influence of admixture in complex diseases.
3. Compare ethnolinguistic, genetic, and geographic data to improve our understanding of genetic variation and ethnolinguistic diversity in eastern and southern African populations and the relationship between them.
4. Identify genetic variants under ongoing natural selection that contribute to disease susceptibilities

Please note: This item is only available as part of the ASHG 2024 Annual Meeting Digital Pass.