Workshop: All of Us & AnVIL Imputation Service

The NIH’s All of Us Research Program and NHGRI’s Genomic Analysis Visualization and Informatics Lab Space (AnVIL) are collaborating to build an imputation service, backed by the largest imputation panel in the world. The panel is derived from whole genome data of over 515,000 participants, including more than 250,000 from non-European ancestries.  Attendees will hear about the development of the service, learn to submit data to the service for imputation, and perform a down stream analysis calculating a polygenic risk score on data imputed with the service. 

Participants will be provided with a test vcf to submit to the service, and will be instructed in the use of a dedicated command line tool for interacting with the service.  PRS calculation will be performed using PLINK.

Learning Objectives:

• Illustrate the utility of imputation in genomic analysis 

• Apply the AoU/AnVIL imputation service to genomic data 

• Evaluate the accuracy of imputed datasets 

• Plan future analyses that can be enhanced using imputation 

Are you attending ASHG 2025 in Boston, MA, this October? You may be eligible for a registration discount for this Virtual Workshop.

If you have purchased a ticket to any of these ASHG 2025 events, please use code ASHGws-50 for a discount on your registration for this workshop!

• ASHG 2025 Career Development Panel: Starting a Lab, Then Vs Now
• ASHG 2025 Leadership Workshop: Managing People, Projects, and Progress
• ASHG 2025 Lessons from the Field: A Dialogue on Promoting Opportunity and Engagement in Human Genetics and Genomics
• ASHG 2025 Strategies for Communicating Your Science to a Variety of Audiences
• Behind-the-Scenes: Publications Workshop
• ASHG 2025 UCSC Genome Browser Short Course
• ASHG 2025 Workshop: Applications of Population Descriptors in Genomics Research
• ASHG 2025 Workshop: Assessing Genetic Variants for Antisense Oligonucleotide Therapy Amenability: Practical Training Workshop and Discussion
• ASHG 2025 Workshop: Nextflow Run: Getting Started with Nextflow for Bioinformatics
• ASHG 2025 Workshop: Pathway Analysis for All: Hands-On Training with Reactome
• ASHG 2025 Workshop: The Human Pangenome: Data, Tools, and Workflows
• ASHG 2025 Workshop: The Michigan Imputation Server: Data Preparation, Genotype Imputation, and Data Analysis

To check that you have purchased an add-on experience, please refer to your ASHG 2025 registration confirmation email or access order information by logging into your account at ashg.org. Please contact digitalprograms@ashg.org if you have any questions or issues in applying your discount code.