In vivo correction of human phenylketonuria variants via base and prime editing

Dominique Brooks is a third-year Ph.D. student in the Gene Therapy and Vaccines Program at University of Pennsylvania. Her research focuses on the development of gene-editing therapies aimed at addressing metabolic diseases, with a specific focus on phenylketonuria. Dominique earned her Bachelor of Science degree from University of Maryland, Baltimore County and distinguished herself as a Meyerhoff Scholar, Howard Hughes Medical Institute Scholar, MARC (Maximizing Access to Research Careers) Scholar, and Barry Goldwater Scholar. Beyond her academic pursuits, Dominique is an IDEAL (Inclusion, Diversity, Equity, and Learner) Research fellow and outreach co-chair for the E.E. Just Biomedical Society where she is an advocate for the advancement of science and education, particularly for those from underrepresented backgrounds. 

An actively practicing cardiologist and committed teacher, Kiran Musunuru, M.D., Ph.D., M.P.H., M.L., is Professor of Cardiovascular Medicine and Genetics in the Perelman School of Medicine at the University of Pennsylvania. His research focuses on the genetics of cardiovascular and metabolic diseases and seeks to identify genetic factors that protect against disease and use them to develop gene-editing therapies. He recently served as Editor-in-Chief of the scientific journal Circulation: Genomic and Precision Medicine. He is author of The CRISPR Generation: The Story of the World's First Gene-Edited Babies and Genome Editing: A Practical Guide to Research and Clinical Applications. He is co-founder and Senior Scientific Advisor of Verve Therapeutics.