Incorporating Polygenic Risk Scores and Social Determinants of Health Across Populations

Dr. Sara Cromer and Dr. Dave Conti will review the commonly used population descriptors, polygenic scores, and social determinants of health measures, identifying the nuances in measurement and interpretation. They will then turn to analytic and ethical considerations for modeling polygenic risk and SDoH jointly across diverse populations.

Overview of Presentation:

• Define and explore the complexity of commonly used population descriptors, polygenic scores, and social determinants of health
• Identify important considerations and best practices in modeling polygenic risk and social determinants jointly
• Highlight key ethical considerations when applying these measures across genetically and socially diverse populations