Featured Plenary Abstract Session I

In the opening plenary session of the 2025 ASHG Annual Meeting, participants heard cutting-edge science using a variety of approaches including massively parallel reporter assays, Mendelian Randomization, multi-omics, quantitative trait locus colocalization with genome wide association study results, and large language models. These studies advance our understanding of functional effects of non-coding variations, GLP1 agnosim, spaceflight-induced physiological changes, genetic architecture of central obesity, and the power of LLMs to aid in clinical genetics workflows.

Learning Objectives

*    Examine obesity mechanisms, genetics of sex-based central fat patterns & potential GLP1R agonist biomarkers
*    Evaluate the functional effects of 5' UTR variants and spaceflight-induced molecular signatures
*    Compare performance of large language models to clinical geneticists when diagnosing genetic conditions using case-based scenarios