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ASHG Annual Meeting Highlights 2026

  • Register
    • Regular Member - $199
    • Early Career Member - $199
    • Resident/Clinical Fellow Member - $199
    • Postdoctoral Fellow Member - $199
    • Graduate Student Member - $199
    • Undergraduate Student Member - $199
    • Emeritus Member - $199
    • Life Member - $199
    • Nonmember - $299
    • Trainee Member - $199

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Pricing: $99 ASHG 2026 attendees (with coupon), $199 ASHG member, $299 nonmember.


Tuesday, October 20 

  • Presidential Welcome and Address 
    • Finding Your Voice in Science: Reflections on Leadership and Resilience (Susan A. Slaugenhaupt, PhD)
  • Plenary Abstract Session I

Wednesday, October 21 

  • Featured Symposia
    • The All of Us Research Program at 10 years: 500,000+ Genomes Advancing Precision Medicine
  • Platform Abstract Sessions
    • Promise and Peril of Sequence-to-Function Models for Variant Effect Predictions
  • Lightning Talks
    • Advances in Population Genetics, Genetic Epidemiology, and Omics
  • Awards Recognition and Presidential Symposium 
    • Communicating Science in an Uncertain World: Evidence, Storytelling, and Public Trust

Thursday, October 22

  • Platform Abstract Sessions
    • The Long and Short of It: Long-Read Genomics from Biobanks to the Clinic
  • Platform Abstract Sessions
    • Pivoting from Gene-Level Analyses to Isoform-Resolved Biology
  • Awards Recognition and Plenary Abstract Session II

Friday, October 23 

  • Featured Symposia
    • The IGVF Consortium: Deciphering the Impact of Genomic Variation on Genome Function
  • Platform Abstract Sessions
    • What’s Next in Genetics and Genomics: Late Breaking Science
  • Platform Abstract Sessions
    • MAMO: Multi-Ancestry-Aware Multi-Omics Analysis for Complex Diseases
  • Awards Recognition and Plenary Abstract Session III

Saturday, October 24 

  • Distinguished Speakers Symposium  
    • Globalizing Human Genetics: From Discovery Through Implementation

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Tuesday, October 20
Presidential Welcome and Address
Open to view video.
Open to view video. Finding Your Voice in Science: Reflections on Leadership and Resilience with ASHG President Susan A. Slaugenhaupt, PhD
You must register to access.
Plenary Abstract Session I
Open to view video.
Open to view video. This plenary session shows how genomic science is moving from discovery into real diagnoses and better patient care at scale. From artificial intelligence that reads rare disease genomes, to a richer map of immune gene diversity in African populations, to multi-omic detective work that cracks previously unsolvable cases in Canada, to population-wide screening that reached hundreds of thousands of people across more than a dozen health systems, the talks reveal a field rapidly translating data into impact. Together they highlight how computation, diverse representation, and health system partnerships are expanding both the reach and the equity of human genetics.
You must register to access.
Wednesday, October 21
Featured Symposia: The All of Us Research Program at 10 years: 500,000+ Genomes Advancing Precision Medicine
Open to view video.
Open to view video. This session will explore the present and future of genomics in the All of Us Research Program at ten years from launch. With > 500K whole genomes now released, All of Us offers important strategic lessons on building a national genomic resource to advance precision medicine and genomic discovery in the United States. Four talks will (1) summarize the genomic goals of the program and controversies/challenges that were addressed to achieve release at scale, (2) describe the current multimodal data and its practical access on a secure cloud platform, (3) highlight recent discoveries and methodological advances, and (4) address the global reach of the program and potential for cross-cohort analyses. A moderated panel will examine lessons learned for the development of future large resources, discuss how All of Us resources is/will enable rapid scientific breakthroughs and offer diverse perspectives on the benefits/challenges of centralized resource development for catalyzing discovery.
You must register to access.
Platform Abstract Session: Promise and Peril of Sequence-to-Function Models for Variant Effect Predictions
Open to view video.
Open to view video. Sequence-to-function machine-learning models promise to predict the functional consequences of genetic variants directly from DNA, yet their reliability across contexts and populations remains an open question. This session pairs advances such as genome-wide in silico saturation mutagenesis with AlphaGenome and improved expression prediction in diverse populations against rigorous independent benchmarking from the Critical Assessment of Genome Interpretation and new measures of when a model's predictions can be trusted. Together the talks weigh both the transformative potential and the current limitations of these models, offering a grounded view of how sequence-to-function prediction can responsibly inform variant interpretation.
You must register to access.
Lightning Talks: Advances in Population Genetics, Genetic Epidemiology, and Omics
Open to view video.
Open to view video. This session highlights cutting-edge advances in evolutionary and population genetics, statistical genetics, and multi-omics technologies that are transforming our understanding of human biology and disease. Presentations span ancient and modern population genomics, genetic epidemiology, polygenic risk prediction, proteomics, single-cell and spatial omics, and long-read sequencing.
You must register to access.
Awards Recognition
Open to view video.
Open to view video. Yusuke Nakamura, MD, PhD, Lifetime Achievement Award recipient and, Nancy B. Spinner, PhD, Mentorship Award
You must register to access.
Presidential Symposium
Open to view video.
Open to view video. Communicating Science in an Uncertain World: Evidence, Storytelling, and Public Trust
You must register to access.
Thursday, October 22
Platform Abstract Session: The Long and Short of It: Long-Read Genomics from Biobanks to the Clinic
Open to view video.
Open to view video. This session showcases how long-read sequencing and pangenome-based approaches are enabling comprehensive characterization of structural variation, haplotypes, and previously inaccessible regions of the genome. Spanning population-scale biobanks, diverse ancestry cohorts, and clinical rare disease studies, the talks highlight the growing impact of long-read genomics on variant discovery, association studies, and precision medicine.
You must register to access.
Platform Abstract Session: Pivoting from Gene-Level Analyses to Isoform-Resolved Biology
Open to view video.
Open to view video. This session highlights a shift in human genomics from gene-level analyses to isoform-resolved biology, leveraging long-read sequencing to uncover transcriptional regulation across aging, development, populations, and disease. Talks describe the emergence of long-read transcriptomics as a transformative platform for understanding how genetic variation shapes transcript architecture across the lifespan and across human populations, positioning isoform biology as a central approach in functional genomics and precision medicine.
You must register to access.
Awards Recognition
Open to view video.
Open to view video. Aravinda Chakravarti, PhD, Leadership Award recipient and Rebecca Ahrens-Nicklas, MD, PhD, Early Career Award recipient
You must register to access.
Plenary Abstract Session II
Open to view video.
Open to view video. This plenary session showcases how human pangenomes, long-read sequencing, single-cell genomics, and donor-specific genome assemblies are uncovering previously inaccessible genetic and somatic variation across human tissues, development, and disease. Together, these studies reveal new mechanisms underlying HLA regulation, somatic mosaicism, telomere inheritance, and congenital heart disease, demonstrating how advanced genomic technologies are reshaping our understanding of human biology and precision medicine.
You must register to access.
Friday, October 23
Featured Symposia: The IGVF Consortium: Deciphering the Impact of Genomic Variation on Genome Function
Open to view video.
Open to view video. Understanding the functions of DNA variants could reveal novel human biology, uncover mechanisms of disease risk, and guide development of new drugs or diagnostics. Yet, understanding how genomic variation alters genome function to influence phenotype has proven challenging. To unlock these insights, we need a systematic and comprehensive catalog of genome function and the molecular and cellular effects of genomic variants. Toward this goal, the NHGRI Impact of Genomic Variation on Function (IGVF) Consortium is combining single-cell mapping, genomic perturbations, and predictive modeling to connect variants to functions to phenotypes. IGVF has created initial maps describing how coding variants alter protein activity, how noncoding variants and elements regulate gene expression, and how such effects connect through cellular molecular networks. These maps can be used to understand genome regulation, interpret variants of uncertain significance, and advance precision health.
You must register to access.
Platform Abstract Session: What's Next in Genetics and Genomics: Late Breaking Science
Open to view video.
Open to view video. This Late-Breaking Abstract Platform Session features timely discoveries spanning AI applications for cancer detection, genetic influences on dreaming and psychiatric risk, mechanisms underlying type 2 diabetes risk, and global studies of prostate cancer disparities.
You must register to access.
Platform Abstract Session: MAMO: Multi-Ancestry-Aware Multi-Omics Analysis for Complex Diseases
Open to view video.
Open to view video. This session focuses on advances in multi-ancestry–aware, multi-omics analyses to improve the resolution, biological interpretation, and translational utility of complex disease genetics. Presentations will demonstrate how integrating diverse populations enhances fine-mapping precision and functional annotation, substantially narrowing candidate causal variants and revealing regulatory elements, as shown using combining GWAS with eQTLs, proteomics, and single-cell/spatial transcriptomics uncovers immune, circadian, and spatio-cellular mechanisms underlying disease susceptibility. Together, this session underscores the critical role of diverse populations and integrative multi-omics approaches in advancing equitable, biologically informed precision medicine.
You must register to access.
Awards Recognition
Open to view video.
Open to view video. Roxanne Khamsi, Advocacy Award recipient; Robbee Wedow, PhD, Education Award recipient; and Wendy Chung, MD, PhD, Scientific Achievement Award recipient
You must register to access.
Plenary Abstract Session III
Open to view video.
Open to view video. In this plenary session, speakers will discuss large-scale genomic, functional, and population-based analyses that will shed light on mechanisms in a variety of disease contexts. The first talk will discuss transcriptomics profiling for precancerous lesions, followed by a mechanism for modifying repeat instability in Huntington's disease, a heritability study in large multi-generation pedigrees and finishing with a fine-mapping method for gene and phenotype interactions.
You must register to access.
Saturday, October 24
Distinguished Speakers Symposium
Open to view video.
Open to view video. Globalizing Human Genetics: From Discovery Through Implementation
You must register to access.