In this workshop, we will show how to perform genomic variant interpretation and analysis using OpenCRAVAT, a biologist-friendly open source software framework for the annotation of human genetic variation.

This workshop will take you through the annotation process for Ensembl/GENCODE and MANE, allowing you to experience the rationale, challenges and conflicts involved in annotation and transcript selection.

This interactive workshop is intended for anyone interested in learning how to impute genotypes and to use the imputed genotypes, with a special focus on up-coming reference panels, including the multi-ancestry panel from the TOPMed program.

This workshop will introduce participants to three important ENCODE resources: 1) The ENCODE data portal, 2) SCREEN, and 3) Juicebox.

While existing users are familiar with it, they are often not aware of the latest valuable additions to the Browser's capabilites. The workshop will focus on useful features, mostly introduced in the past few years, that we know from experience have not been discovered by many of our most ardent users.